Sekaric, Wegerich, Gendy, Guo, Ward, Goergen, Amin, Wilson, Hakim, Paramethiotis, Steinhubl
Vaccine-induced inflammation is detectable by identifying changes in an individual’s physiologic parameters when the pre-vaccine baseline normal variation in those parameters is known. We developed a multivariate digital biomarker that incorporates changes in multiple continuously monitored physiologic data streams, and their interactions with each other, as a more sensitive measure of the degree and duration of vaccine induced inflammation.